Positive allosteric modulators of mglur2

A compound according to Formula I

• wherein:
• X is selected from C and N;
• Y is C1-6alkyl;
• R1 is selected from the group consisting of:
• (1) C2-8alkyl,
• (2) C2-8alkenyl,
• (3) C2-8alkynyl,
• (4) C3-6cycloalkyl-(CH2)p—, wherein p is 1, 2, 3 or 4, and
• (5) benzyl,
• wherein groups (1) to (5) above are optionally substituted with 1 to 3 R2 groups;
• each R2 is independently selected from the group consisting of:
• halo, OH, C1-4alkyl, C1-4alkoxy, CF3, —OCF3 and —CN;
• ring A is selected from aryl and heteroaryl, wherein said aryl and heteroaryl are optionally substituted with one or more R3 groups up to the maximum number of substitutable positions;
• each R3 is independently selected from the group consisting of:
• (1) halo,
• (2) C1-8alkyl,
• (3) C2-6alkenyl,
• (4) C2-6alkynyl,
• (5) C3-6cycloalkyl,
• (6) C1-6alkoxy,
• (7) C3-6cycloalkoxy,
• (8) —CN,
• (9) —OH,
• (10) —C(O)—O—C1-4alkyl,
• (11) —C(O)—C1-4alkyl,
• (12) —N(R)2,
• (13) —C(O)—N(R)2,
• (14) —S(O)k—C1-4alkyl, wherein k is 0, 1 or 2,
• (15) -aryl,
• (16) -heteroaryl,
• (17) -heterocycle,
• (18) —C(O)-aryl,
• (19) —N(R)-aryl,
• (20) benzyl,
• (21) benzyloxy,
• (22) aryl-O—,
• (23) heteroaryl-O—,
• (24) heterocycle-O—
• (23) —CO2H,
• (24) —SH,
• (25) —SO2N(R)R,
• (26) —N(R)C(O)N(R)R,
• (27) —N(R)C(O)C1-4alkyl,
• (28) —N(R)SO2N(R)R,
• (29) —B(OH)2,
• (30) heteroaryl-CH2—,
• (31) heterocycle-CH2—,
• (32) aryl-C(O)—N(R)—CH2—,
• (33) heteroaryl-C(O)—N(R)—CH2—,
• (34) heterocycle-C(O)—N(R)—CH2—,
• (35) aryl-C(O)—N(R)—CH2—,
• (36) heteroaryl-CH2—C(O)—N(R)—CH2—,
• (37) heterocycle-CH2—C(O)—N(R)—CH2—, and
• (38) C1-6alkyl-C(O)—N(R)—CH2—,
• wherein groups (2) to (7), (10), (11), (14) to (24), (27) and (30) to (38) above are optionally substituted from one up to the maximum number of substitutable positions with one or more substituents independently selected from the group consisting of:
• OH, CN, halo, —N(R)2, —C(O)—N(R)2, —CH2—N(R)2, —C(O)—CH2—N(R)2, carboxy, —C(O)—O—C1-4alkyl, —C(O)—C(R)2—C(O)—O—C1-4alkyl, —CH2—C3-6cycloalkyl, C1-4alkoxy, C1-4alkylamino, acetyl, acetylamino, methylsulfonyl, methylsulfonylamino, phenyl, heterocycle, heteroaryl, heteroaryl-C(O)—, C1-4alkyl and C1-4alkyl-C(O)—, said C1-4alkyl, C1-4alkyl-C(O)—, heteroaryl and heteroaryl-C(O)-optionally substituted with 1 to 3 halogen atoms and hydroxyl, and heteroaryl and heteroaryl-C(O)— additionally optionally substituted with methyl, and each R is independently selected from the group consisting of:
• H and C1-4alkyl;
• aryl at each occurrence is independently selected from the group consisting of:
• phenyl, naphthyl, anthryl and phenanthryl;
• heteroaryl at each occurrence independently means a 5- or 6-membered monocyclic aromatic or 9- or 10-membered bicyclic aromatic, wherein at least one atom in the aromatic is selected from N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide;
• heterocycle at each occurrence independently means a 5- or 6-membered monocyclic non-aromatic ring or 9- or 10-membered bi- or spiro-cyclic non- or partially-aromatic ring, each optionally substituted with 1 to 2 oxo groups, wherein at least one atom is selected from N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide;
• and pharmaceutically acceptable salts thereof.