Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use

A compound having the formula:

• wherein each of Compounds A-H include R2′ and one of:
• R4′, R5′, R6′, and R7′, wherein one of R2′, R4′, R5′, R6′, and R7′ is selected from an alkyl group having from 1 to 6 carbons, an alkyl amino group having from 1 to 6 carbons, an alkyl group having a hydroxylic group and having from 1 to 6 carbons, and a methoxy group, wherein the other of R2′, R4′, R5′, R6′, and R7′ is a substituted or unsubstituted group selected from:
• an aliphatic group, an alkoxy group, a cycloalkyl group, an aryl group, a heteroaryl group, and a heterocyclic group, wherein each of RN1, RP1, RP2, RP3, RP4, RP5, RP6, RP7, and RP8 are independently a substituted or unsubstituted group selected from:
• an aliphatic group, an alkoxy group, a cycloalkyl group, an aryl group, a heteroaryl group, and a heterocyclic group.