Substituted androst-4-ene diones
AssigneesEmory University, Hauptman-Woodward Medical Research Institute, Inc., Research Foundation of the State of New York
InventorsHuw Davies, Debashis Ghosh, Daniel Morton
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Abstract
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.
Claims16
A compound of Formula A
- or salts, ester, or prodrug thereof, wherein
- ————— represents a bond either absent or present as a double bond and R″ is absent when the double bond is present or is H when the bond is absent;
- Z′ is hydrogen or is OR′ and Z is hydrogen or is OR, wherein when Z′ is hydrogen, Z is OR and when Z is hydrogen Z′ is OR′;
- R and R′ are independently selected from an alkyl, alkenyl, or alkynyl group optionally substituted with one or more substituents.
Dependencies are inferred from the claim text.