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US 2013/0157984 A1Published application
Prostaglandin-bisphosphonate conjugate compounds, methods of making same, and uses thereof
AssigneeSimon Fraser University
InventorsRobert N. Young, Stephen Arns, Anne Moreau, Monzur Morshad, Romelo Gibe
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Abstract
The invention provides in part, conjugate compounds. The invention also provides synthesis methods for making the compounds, and uses of the compounds.
Claims20
A compound according to Formula I, or a pharmaceutically acceptable salt thereof:
- wherein:
- X is —C—, —S—, —O—, or —NH—;
- R2 and R3 are each independently —H or halo;
- Ar is aryl;
- W is —H, —C(O)V, or —C(O)OV;
- Y is optionally substituted tetrazole, —C(O)OR1, or —C(O)NHSO2R′;
- n is 1, 2 or 3;
- V is optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted heteroalkyl;
- R1 is H or optionally substituted lower alkyl;
- R′ is optionally substituted lower alkyl or optionally substituted aryl;
- and
- is a double or single bond,
- and wherein Y or W is conjugated to a bisphosphonate moiety.
10 more elements
A compound according to Formula IV or V, or a pharmaceutically acceptable salt thereof:
- wherein:
- X is —C—, —S—, —O—, or —NH—;
- R1 and R2 are each independently H, small alkyl, cycloalkyl group or CF3;
- R3 is a electron donating or electron withdrawing group;
- m is 1, 2, or 3;
- n is 1, 2, 3, or 4;
- and
- o is 1, 2, 3, or 4.
5 more elements
Dependencies are inferred from the claim text.