Substituted indole derivatives
AssigneeNovartis AG
InventorsNigel Graham COOKE, Rita RAMOS, Karen KAMMERTOENS, Maurice VAN EIS
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Abstract
The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
Claims17
A compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof,
- Wherein
- X is CH or N;
- R is H or PO3H2;
- R1 is H;
- or C1-4alkyl;
- R2 is H;
- or C1-4alkyl;
- R3 is H;
- C1-4alkyl;
- CN;
- Hal;
- or OH;
- and
- R4 and R5 are independently from each other H, or C1-4alkyl;
- or R4 and R5 form together with the carbon atom to which they are attached a 3-6 membered cycloalkyl group.
(canceled)
A crystalline form of phosphoric acid mono-[3-[3-(4,7-diaza-spiro[2.5]oct-7-yl)-isoquinolin-1-yl]-4-(7-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-pyrrol-1-ylmethyl]ester, which has an X-ray powder diffraction pattern with at least one of the following peaks at an angle of refraction 2 theta (θ) of 9.525, 16.356, 17.091, 18.005, 20.859, each ±0.2, especially as depicted in FIG. 1 and/or Table 1.
Dependencies are inferred from the claim text.