Method of drug delivery for bone anabolic protein
AssigneesIpsen Pharma S.A.S., Radius Health, Inc.
InventorsMichael J. Dey, Nathalie Mondoly, Benedicte Rigaud, Bart Henderson, C. Richard Lyttle
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Abstract
The present invention provides a storage-stable composition containing a parathyroid hormone-related protein (PTHrP) and methods of using a PTHrP and the PTHrP compositions described herein to treat osteoporosis, to increase bone mass or to increase bone quality. The composition is storage stable, in sterile form, and in general may be stored at room temperature for at least several weeks to allow convenient parenteral administration to human patients.
Claims13
-2. (canceled)
A method of stimulating bone growth in a subject in need thereof comprising administering to said subject a storage stable composition comprising:
- a) a PTHrP having the sequence [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2 (SEQ ID NO.:
- 2);
- and
- b) an effective amount of buffer to maintain the pH in a range of about 4.5 to about 5.6.
Dependencies are inferred from the claim text.