Loading patent…
AssigneeBristol-Myers Squibb Company
InventorsStuart EMANUEL, Linda ENGLE, Ray CAMPHAUSEN, Martin C. WRIGHT, Ginger CHAO, Marco GOTTARDIS, Joan CARBONI
Estimating the term…
The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
An antibody-like protein comprising a tenth fibronectin type III domain (10Fn3) that binds EGFR with a KD of less than 500 nM, wherein the EGFR binding 10Fn3 comprises a BC loop having the amino acid sequence set forth in amino acids 21-30 of SEQ ID NO:
An antibody-like protein comprising a tenth fibronectin type III domain (10Fn3) that binds EGFR with a KD of less than 500 nM, wherein the EGFR binding 10Fn3 comprises a BC loop having the amino acid sequence XgWAPVDRYQXh (SEQ ID NO:
An antibody-like protein dimer comprising a tenth fibronectin type III domain (10Fn3) that binds IGF-IR with a KD of less than 500 nM covalently or non-covalently linked to a 10Fn3 that binds EGFR with a KD of less than 500 nM;
An antibody-like protein dimer comprising a tenth fibronectin type III domain (10Fn3) that binds IGF-IR with a KD of less than 500 nM covalently or non-covalently linked to a 10Fn3 that binds EGFR with a KD of less than 500 nM;
An antibody-like protein dimer comprising a tenth fibronectin type III domain (10Fn3) that binds IGF-IR with a KD of less than 500 nM covalently or non-covalently linked to a 10Fn3 that binds EGFR with a KD of less than 500 nM;
An antibody-like protein dimer comprising a tenth fibronectin type III domain (10Fn3) that binds IGF-IR with a KD of less than 500 nM covalently or non-covalently linked to a 10Fn3 that binds EGFR with a KD of less than 500 nM;
An antibody-like protein comprising a tenth fibronectin type III domain (10Fn3) that binds EGFR with a KD of less than 500 nM, wherein the EGFR binding 10Fn3 comprises a BC loop comprising the amino acid sequence XXXXXXYQ, a DE loop comprising the amino acid sequence XX(V/I/L/M/A)X, and an FG loop comprising the amino acid sequence (D/N)Xn, wherein X is any amino acid and n is 9-14 amino acids.
Dependencies are inferred from the claim text.