Neurotrophic peptides
AssigneeThe Research Foundation for Mental Hygiene, Inc.
InventorsKhalid Iqbal, Inge Grundke-Iqbal
Life of this patent
Estimating the term…
Abstract
The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO: 1) and alternatively comprising an adamantyl group at the C- and/or N-terminal end. The neurotrophic peptide can rescue cognition, correct impairments in neural cell proliferation and synaptic plasticity, and thus address the cognitive defects associated with Alzheimer's disease.
Claims18
A method of treating a subject having Alzheimer's disease comprising the step of administering a therapeutic amount of at least a portion of a neurotrophic peptide having the amino acid sequence VGDGGLFEKKL (SEQ ID NO:
- 1).
A method of treating a subject having Alzheimer's disease comprising the step of administering a therapeutic amount of at least a portion of a neurotrophic peptide having the amino acid sequence VGDGGLFEKKL (SEQ ID NO:
- 1) bound to an adamantane building block.
Dependencies are inferred from the claim text.