Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof

An isolated peptide comprising

• (a) one or more granulin units of Granulin/epithelin precursor (GEP) selected from the group consisting of:
• granulin units F (amino acids 126-178 of SEQ ID NO:
• 1), A (amino acids 284-335 of SEQ ID NO:
• 1), and C (amino acids 366-416 of SEQ ID NO:
• 1);
• and
• (b) one or more linker units of GEP,
• wherein the peptide antagonizes TNFR1 or TNFR2 signaling, and wherein the peptide is a portion or mixed portion of the full-length GEP sequence.

An isolated peptide comprising:

• (a) a fragment of GEP selected from the group consisting of:
• at least ½F (amino acids 153-178 of SEQ ID NO:
• 1);
• at least ½A (amino acids 284-304 of SEQ ID NO:
• 1);
• and at least ½C (amino acids 366-392 of SEQ ID NO:
• 1);
• and
• (b) one or more linker units of GEP,
• wherein the peptide antagonizes TNFR1 or TNFR2 signaling, and wherein the peptide is a portion or mixed portion of the full-length GEP sequence.