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AssigneeAlize Pharma SAS
InventorsAart Jan VAN DER LELY, Thierry ABRIBAT
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A method and a composition for decreasing ghrelin levels and/or decreasing ghrelin/unacylated ghrelin ratio in a subject, the method comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject wherein a reduction in ghrelin levels and/or a reduction in ghrelin/unacylated ghrelin ratio is beneficial to the subject. Also, use of ghrelin level and/or ghrelin/unacylated ghrelin ratio as biomarkers for determining a subject's likelihood of responding to and/or benefiting from administration of unacylated ghrelin.
A method for decreasing ghrelin levels in a subject, comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject.
A method for preventing weight gain in a subject following diet-induced weight loss, comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject.
A pharmaceutical composition comprising an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable diluent for decreasing ghrelin levels in a subject.
A method for screening within a population of subjects suffering from diabetes, Prader-Willi Syndrome, obesity, insulin resistance or hyperphagia, which subjects within the population are susceptible of benefiting from an administration of unacylated ghrelin, a fragment thereof or an analog thereof, comprising:
Dependencies are inferred from the claim text.