Glucagon Superfamily Peptides Exhibiting Glucocorticoid Receptor Activity
AssigneeIndiana University Research and Technology Corporation
InventorsRichard D. DiMARCHI, Bin YANG
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Abstract
Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.
Claims49
A compound comprising the structure Q-L-Y;
- wherein Q is a glucagon superfamily peptide;
- Y is a GR ligand which activates a glucocorticoid receptor with an EC50 of about 1 μM or less, and has a molecular weight of up to about 1000 daltons;
- and
- L is a linking group or a bond, wherein Q-L is attached to position 3 or 17 of the GR ligand.
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Dependencies are inferred from the claim text.