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AssigneeThe Trustees of Columbia University in the City of New York
InventorsJonathan BARASCH, Neal Paragas
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In some embodiments, the present invention is directed to compositions and methods for the treatment and prevention of urinary tract infections (UTIs) and urosepsis. In some embodiments, the methods of the invention comprise administering to a subject in need thereof a therapeutically effective amount of an agent that stimulates genito-urinary tract epithelial cells to produce NGAL, and/or an NGAL protein or a functional derivative thereof, and optionally also administering to the subject an additional agent useful for treating or preventing UTI or urosepsis. In other embodiments, the present invention also provides methods of screening for agents that stimulate urinary tract epithelial cells to produce NGAL.
A method for treating or preventing a bacterial infection of the urinary tract, or urosepsis associated therewith, in a subject, the method comprising administering to the subject a therapeutically effective amount of one or more agents selected from the group consisting of:
A method for treating or preventing bacterial infection of the urinary tract, or urosepsis associated therewith, in a subject, the method comprising stimulating genito-urinary tract epithelial cells of the subject to produce NGAL.
A pharmaceutical composition for use in treating or preventing a bacterial urinary tract infection, or urosepsis associated therewith, the composition comprising a therapeutically effective amount of an agent that stimulates genito-urinary tract epithelial cells to produce NGAL, and a therapeutically effective amount of an NGAL protein or a functional derivative thereof.
A method of identifying an agent that stimulates epithelial cells of the urinary tract to produce NGAL mRNA or NGAL protein, the method comprising:
A method of identifying an agent that stimulates epithelial cells of the urinary tract to produce NGAL mRNA or NGAL protein, the method comprising:
Dependencies are inferred from the claim text.