Glucagon analogues

A compound having the formula:

• R1—Z—R2
• wherein
• R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl;
• R2 is OH or NH2;
• and
• Z is a peptide having the formula I:
• (I)
• (SEQ ID NO:
• 85)
• His-X2-X3-X4-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-
• Tyr-Leu-X15-Ser-X17-Ala-Ala-X20-X21-Phe-Val-X24-
• Trp-Leu-X27-X28-Ala;
• wherein
• X2 is Aib, Ser or Gly;
• X3 is Gln, Glu, Gly, His, Phe, Leu, Trp, Tyr, Val, Arg, Ala, Ser, Ile, Pro, Hph, Hse, Cit, 1-NaI or 3-(heterocyclyl)alanine;
• X4 is Gly, Ala, D-Ala, Val, Aib, Leu, D-Leu, Pro, Glu, Phe, D-Phe, Arg or Lys;
• X15 is Asp or Glu;
• X17 is Arg or X;
• X20 is Arg, His or X;
• X21 is Asp or Glu;
• X24 is Ala or X;
• X27 is Leu or X;
• X28 is Arg or X;
• wherein each residue X is independently selected from the group consisting of Glu, Lys, Ser, Cys, Dbu, Dpr and Orn;
• and wherein the side-chain of at least one amino acid residue X is optionally conjugated to a lipophilic substituent having the formula:
• (i) Z1, wherein Z1 is a lipophilic moiety conjugated directly to the side chain of X;
• or
• (ii) Z1Z2, wherein Z1 is a lipophilic moiety, Z2 is a spacer, and Z1 is conjugated to the side chain of X via Z2;
• with the proviso that if X3 is Gln, then X4 is not Gly.