Reducing transmission of sexually transmitted infections
AssigneesThe Regents of the University of California, University of Rochester
InventorsStephen Dewhurst, Bradley Nilsson, Joanna Olsen, Jerry Yang
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Abstract
Described herein are compositions and methods for treating or preventing a sexually transmitted infection in a subject.
Claims47
A method of treating or preventing a sexually transmitted infection in a subject, the method comprising administering to the subject a semen-derived enhancer of viral infection (SEVI)-binding agent, wherein the agent comprises a compound of the following formula:
- or a pharmaceutically acceptable salt or prodrug thereof, wherein:
- R1, R2, R3, R4, R5, R6, R7, and R8 are each independently selected from hydrogen, halogen, hydroxyl, trifluoromethyl, substituted or unsubstituted thio, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted amino, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted C1-12 heteroalkyl, substituted or unsubstituted C2-12 heteroalkenyl, substituted or unsubstituted C2-12 heteroalkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- and
- R9 and R10 are each independently selected from hydrogen, substituted or unsubstituted C1-20 alkyl, substituted or unsubstituted C2-20 alkenyl, substituted or unsubstituted C2-20 alkynyl, substituted or unsubstituted C1-20 heteroalkyl, substituted or unsubstituted C2-20 heteroalkenyl, substituted or unsubstituted C2-20 heteroalkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
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A method of treating or preventing a sexually transmitted infection in a subject, the method comprising administering to the subject a semen-derived enhancer of viral infection (SEVI)-binding small molecule, wherein the SEVI-binding small molecule comprises a hydrophobic molecule, wherein the hydrophobic molecule incorporates into and binds the SEVI-fibrils.
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A method of treating or preventing a sexually transmitted infection in a subject, the method comprising administering to the subject a semen-derived enhancer of viral infection (SEVI)-binding small molecule, wherein the SEVI-binding small molecule comprises an anionic polypeptide supramolecular assembly.
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A pharmaceutical composition comprising:
- (a) a first agent, wherein the agent comprises a SEVI-binding agent comprising a compound of the following formula:
- or a pharmaceutically acceptable salt or prodrug thereof, wherein:
- R1, R2, R3, R4, R5, R6, R7, and R8 are each independently selected from hydrogen, halogen, hydroxyl, trifluoromethyl, substituted or unsubstituted thio, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, substituted or unsubstituted amino, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted C1-12 heteroalkyl, substituted or unsubstituted C2-12 heteroalkenyl, substituted or unsubstituted C2-12 heteroalkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- and
- R9 and R10 are each independently selected from hydrogen, substituted or unsubstituted C1-20 alkyl, substituted or unsubstituted C2-20 alkenyl, substituted or unsubstituted C2-20 alkynyl, substituted or unsubstituted C1-20 heteroalkyl, substituted or unsubstituted C2-20 heteroalkenyl, substituted or unsubstituted C2-20 heteroalkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- and
- (b) a second agent selected from the group consisting of an anti-viral, an anti-bacterial, or an anti-fungal agent.
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A pharmaceutical composition comprising:
- (a) a first agent, wherein the first agent comprises a semen-derived enhancer of viral infection (SEVI)-binding small molecule, wherein the SEVI-binding small molecule comprises a hydrophobic molecule, wherein the hydrophobic molecule incorporates into and binds the SEVI-fibrils.
- (b) a second agent selected from the group consisting of an anti-viral, an anti-bacterial, and an anti-fungal agent.
A pharmaceutical composition comprising:
- (a) a first agent, wherein the agent comprises a semen-derived enhancer of viral infection (SEVI)-binding small molecule, wherein the SEVI-binding small molecule comprises an anionic polypeptide supramolecular assembly.
- (b) a second agent selected from the group consisting of an anti-viral, an anti-bacterial, and an anti-fungal agent.
Dependencies are inferred from the claim text.