Diagnostic autoantibody profiles for the detection and diagnosis of neurodegenerative diseases
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorRobert G. Nagele
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Abstract
The present invention provides methods, compositions, and kits for the detection of neurodegenerative disease specific autoantibodies for the diagnosis of neurodegenerative diseases and risk for developing neurodegenerative diseases, and for the generation of patient-specific neurodegenerative disease diagnostic autoantibody profiles.
Claims20
A method for detecting neurodegenerative disease diagnostic autoantibodies in a subject comprising:
- (a) obtaining an immunoglobulin-containing biological sample from the subject, and
- (b) performing an assay to determine the presence or absence of one or more neurodegenerative disease diagnostic autoantibodies in the biological sample.
A method for diagnosing a neurodegenerative disease in a subject comprising:
- (a) obtaining an immunoglobulin-containing biological sample from the subject,
- (b) performing an assay to determine the presence or absence of one or more neurodegenerative disease diagnostic autoantibodies in the biological sample, and
- (c) diagnosing said neurodegenerative disease if one or more of the disease diagnostic autoantibodies is present.
A method for identifying a subject at risk for developing a neurodegenerative disease comprising:
- (a) obtaining an immunoglobulin-containing biological sample from the subject,
- (b) performing an assay to determine the presence or absence of one or more neurodegenerative disease diagnostic autoantibodies in the biological sample, and
- (c) identifying the subject as at risk for said neurodegenerative disease if one or more of the disease diagnostic autoantibodies is present.
A method of generating a subject-specific, neurodegenerative disease-specific autoantibody profile comprising:
- (a) obtaining an immunoglobulin-containing biological sample from a subject,
- (b) performing an assay to determine the presence or absence of one or more neurodegenerative disease diagnostic autoantibodies in the biological sample, and
- (c) generating a subject-specific neurodegenerative disease-specific autoantibody profile of the disease diagnostic autoantibodies present in the sample.
A substrate on which one or more autoantigens that are specific for a neurodegenerative disease-specific autoantibody are immobilized.
A microarray comprising a substrate on which one or more autoantigens that are specific for a neurodegenerative disease-specific autoantibody are immobilized.
A kit comprising one or more autoantigens that are specific for a neurodegenerative disease-specific autoantibody and means for determining binding of the autoantigen to an antibody in an immunoglobulin-containing biological sample.
Dependencies are inferred from the claim text.