Complex miRNA Sets as Novel Biomarkers for an Acute Coronary Syndrome

A method for diagnosing and/or prognosing of an acute coronary syndrome comprising the steps of:

• (i) determining an expression profile of a miRNA or a set comprising at least two miRNAs representative for an acute coronary syndrome in a blood sample from a human, wherein the nucleotide sequence of said miRNA or the nucleotide sequences of said miRNAs is (are) selected from the group consisting of SEQ ID NO:
• 1 to SEQ ID NO:
• 283, a fragment thereof, and a sequence having at least 80% sequence identity thereto, and
• (ii) comparing said expression profile to a reference, wherein the comparison of said expression profile to said reference allows for the diagnosis and/or prognosis of an acute coronary syndrome and/or applying an algorithm or a mathematical function to said expression profile, wherein the application of said algorithm or mathematical function to said expression profile allows for the diagnosis and/or prognosis of an acute coronary syndrome.

A kit for diagnosing and/or prognosing of an acute coronary syndrome comprising

• (i) means for determining an expression profile of a miRNA or a set comprising at least two miRNAs representative for an acute coronary syndrome in a blood sample from a human, wherein the nucleotide sequence of said miRNA or the nucleotide sequences of said miRNAs is (are) selected from the group consisting of SEQ ID NO:
• 1 to SEQ ID NO:
• 283, a fragment thereof, and a sequence having at least 80% sequence identity thereto;
• and
• (ii) at least one reference and/or algorithm or mathematical function.