Methods of producing t cell populations enriched for stable regulatory t-cells
AssigneeThe USA, as represented by the Secretary, Department of Health and Human Service
InventorsYong Chan Kim, Ethan Shevach
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Abstract
The present invention provides methods for producing cell populations enriched for stable, regulatory T cells (Tregs). In particular, the invention relates to methods for culturing T cells such that the final culture is enriched for stable, regulatory T cells. It also relates to methods for stabilizing regulatory T cells. Also provided are compositions enriched for stable, regulatory T cells, which are useful for treating individuals in need of such treatment. The methods and compositions disclosed herein can also be used to treat an individual suffering from an immune-mediated disease.
Claims19
A method for producing a population of cells having stable, regulatory T cells, the method comprising culturing isolated cells comprising an initial population of regulatory T-cells, in the presence of an oligonucleotide to expand the initial, regulatory T-cells.
A method for stabilizing T regulatory cells, the method comprising culturing isolated cells comprising initial regulatory T-cells, in the presence of an oligonucleotide to expand the initial regulatory T-cell population.
A composition comprising isolated cells, wherein greater than 60% of the isolated cells are stable, regulatory T-cells.
Dependencies are inferred from the claim text.