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US 2013/0157361 A1Published application
Catalytic domains from lysyl oxidase and loxl2
AssigneeGilead Biologics, Inc.
InventorsScott MCCAULEY, Victoria SMITH
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Abstract
Disclosed herein are amino acid sequences, and encoding nucleotide sequences, of isolated catalytic domains of the LOX and LOXL2 proteins from human and mouse. Methods for the preparation and use of these isolated catalytic domains are also provided.
Claims12
An isolated polynucleotide, comprising:
- a nucleotide sequence encoding a polypeptide comprising a catalytic domain of a human or murine LOX or LOXL2 protein, wherein:
- the polypeptide comprises the amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 1, SEQ ID NO:
- 1 without the initial GL residues, SEQ ID NO:
- 3 or SEQ ID NO:
- 3 without the initial TA residues, SEQ ID NO:5, SEQ ID NO:5 without the initial GL residues, and SEQ ID NO:7, SEQ ID NO:7 without the initial TA residues;
- and
- the polypeptide does not contain sequences from the human or murine LOX or LOXL2 protein outside its catalytic domain.
6 more elements
Dependencies are inferred from the claim text.