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US 2013/0157343 A1Published application
Biological methods for preparing adipic acid
AssigneeVerdezyne, Inc.
InventorsStephen PICATAGGIO, Tom Beardslee
Life of this patent
Estimating the term…
Abstract
The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.
Claims30
A genetically modified Candida yeast, comprising:
- a genetic modification that reduces or eliminates a POX4 activity, thereby partially blocking beta oxidation activity;
- a genetic modification that adds or increases a CYP52A15, CYP52A16 or CYP52A19 monooxygenase activity;
- and
- a genetic modification that adds or increases a monooxygenase reductase activity.
1 more element
A genetically modified Candida yeast, comprising:
- a genetic modification that reduces or eliminates a POX5 activity, thereby partially blocking beta oxidation activity,
- a genetic modification that adds or increase a CYP52A15, CYP52A16, or CYP52A19 monooxygenase activity, and
- a genetic modification that adds or increases a monooxygenase reductase activity.
A genetically modified Candida yeast, comprising:
- a genetic modification that reduces or eliminates a POX4 activity and a POX5 activity, thereby blocking beta oxidation activity,
- a genetic modification that adds or increase a CYP52A15, CYP52A16, or CYP52A19 monooxygenase activity, and
- a genetic modification that adds or increases a monooxygenase reductase activity.
Dependencies are inferred from the claim text.