Rhamm binding peptides
AssigneeLondon Health Sciences Centre Research Inc.
InventorsLeonard G. Luyt, Eva A. Turley, Kenneth Virgel Esguerra
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Abstract
The present invention provides for peptides that bind to Receptor for Hyaluronic Acid Mediated Motility (RHAMM) molecules. More specifically, provided are peptides capable of specifically binding RHAMM molecules and capable of binding RHAMM with substantially high affinity. These novel RHAMM-binding peptides provide the basis for new imaging probes that can be used to identify cells expressing RHAMM, and for methods of imaging, prognosis, diagnosis and treatment of conditions associated with RHAMM expression.
Claims32
A RHAMM-binding peptide characterized in that said RHAMM-binding peptide comprises a sequence having a formula EEXEEZ (SEQ ID NO:
- 18), wherein X is selected from alanine or glycine, and Z is selected from tyrosine or glutamic acid, or a functional analog thereof.
A RHAMM-binding peptide characterized in that said RHAMM-binding peptide comprises at least one of the amino acid sequences selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 17, or a functional analog thereof.
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A probe comprising a tubulin-derived, RHAMM-binding peptide and a detectable label capable of being detected by a detection technique.
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An isolated peptide comprising a sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 17.
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Dependencies are inferred from the claim text.