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AssigneeRegeneron Pharmaceuticals, Inc.
InventorsSean Stevens, Tammy T. Huang, Joel H. Martin, Jeanette L. Fairhurst, Ashique Rafique, Eric Smith, Kevin J. Pobursky, Nicholas J. Papadopoulos, James P. Fandl, Gang Chen, Margaret Karow
Estimating the term…
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
An isolated nucleic acid molecule encoding an antibody or antibody fragment which specifically binds human interleukin-6 receptor (hIL-6R), wherein the antibody or antibody fragment comprises three heavy chain complementarity determining region (CDR) sequences and three light chain CDR sequences, wherein the three heavy chain CDR sequences comprise a combination selected from the group consisting of SEQ ID NO:149, 151 and 153;
An isolated nucleic acid molecule encoding an antibody or antibody fragment which specifically binds human interleukin-6 receptor (hIL-6R), wherein the antibody or antibody fragment comprises a heavy chain variable region (HCVR) comprising SEQ ID NO:147, 3 or 179.
An isolated nucleic acid molecule encoding an antibody or antibody fragment which specifically binds human interleukin-6 receptor (hIL-6R), wherein the antibody or antibody fragment comprises a light chain variable region (LCVR) comprising SEQ ID NO:155, 11 or 187.
Dependencies are inferred from the claim text.