Plasmonic assisted systems and methods for interior energy-activation from an exterior source

A method for producing a change in a medium, comprising:

• (1) placing inside the medium to be treated an energy modulation agent and a photoactivatable agent, said energy modulation agent comprising a photon emitter which emits at least one of ultraviolet and visible light into the medium to be treated upon interaction with an initiation energy;
• (2) applying the initiation energy from an energy source including at least one of x-rays, gamma rays, or an electron beam to the medium in order to provide said at least one of ultraviolet and visible light at one or more positions displaced from the energy modulation agent inside the medium to be treated;
• and
• (3) inducing from the light emitted into the medium a photoreactive change to the photoactivatable agent displaced from the energy modulation agent inside the medium to be treated.