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US 2013/0156865 A1Published application
Potentiation induced by pde4 inhibitors in the treatment of leukemia
AssigneeChiesi Farmaceutici S.p.A.
InventorsAntonio Bonati, Paolo Lunghi
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Abstract
Certain PDE-4 inhibitors are useful for the treatment of myeloid and linphoyd malignancies.
Claims20
A combination comprising:
- (A) at least one compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
- n is 0 or 1;
- R1 and R2, which may be the same or different, are independently:
- linear or branched (C1-C6)alkyl, optionally substituted by one or more halogen atoms;
- OR3, wherein R3 is a linear or branched (C1-C6)alkyl group optionally substituted with one or more halogen atoms or C3-C7 cycloalkyl groups;
- or
- HNSO2R4, wherein R4 is a linear or branched (C1-C4)alkyl group optionally substituted with one or more halogen atoms,
- wherein at least one of R1 and R2 is HNSO2R4;
- and
- (B) at least one of:
- (i) at least one retinoid and/or
- (ii) at least one arsenic derivative.
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A method for the treatment of a hematological malignancy, comprising administering an effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
- n is 0 or 1;
- R1 and R2, which may be the same or different, are independently:
- linear or branched (C1-C6)alkyl, optionally substituted by one or more halogen atoms;
- OR3, wherein R3 is a linear or branched (C1-C6)alkyl group optionally substituted with one or more halogen atoms or C3-C7 cycloalkyl groups;
- or
- HNSO2R4, wherein R4 is a linear or branched (C1-C4)alkyl group optionally substituted with one or more halogen atoms,
- wherein at least one of R1 and R2 is HNSO2R4;
- to a subject in need thereof.
6 more elements
Dependencies are inferred from the claim text.