Immunogenic composition
AssigneeToray Industries, Inc.
InventorsYoichiro Koshi, Reiji Nishio, Yoshinori Kakizawa
Life of this patent
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Abstract
An immunogenic composition includes as effective ingredients: an immunogenic micro-particle composed of an antigen-adjuvant microparticle complex wherein an antigen(s) is/are encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydro-phobic segment(s) is/are poly(hydroxy acid); and a surfactant encapsulated in the immunogenic microparticle.
Claims19
An immunogenic composition comprising as effective ingredients:
- an immunogenic microparticle composed of an antigen-adjuvant microparticle complex wherein an antigen(s) is/are encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydrophobic segment(s) is/are poly(hydroxy acid);
- and a surfactant encapsulated in said immunogenic microparticle.
An immunogenic composition comprising as an effective ingredient an immunogenic microparticle obtained by:
- dissolving a surfactant(s) in an aqueous solvent A wherein an antigen(s) is/are dissolved or in a water-immiscible organic solvent B wherein an amphiphilic polymer(s) whose hydrophobic segment(s) is/are poly(hydroxy acid) is/are dissolved, and mixing the resulting mixture to form a reversed-phase emulsion;
- and
- removing the solvent from said reversed-phase emulsion.
An immunogenic composition comprising as an effective ingredient an immunogenic microparticle obtained by a process of producing a particle composed of an antigen-adjuvant microparticle complex associated together, said process comprising:
- mixing an aqueous solvent A wherein an antigen(s) is/are dissolved and a water-immiscible organic solvent B wherein an amphiphilic polymer(s) whose hydrophobic segment(s) is/are poly(hydroxy acid) is/are dissolved, to form a reversed-phase emulsion;
- removing the solvent from said reversed-phase emulsion to obtain an antigen-adjuvant microparticle complex;
- and
- introducing an antigen-adjuvant microparticle complex dispersion C to a liquid phase D wherein a surface modifier is dissolved, followed by removing the dispersion medium;
- wherein a surfactant(s) is/are dissolved in said aqueous solvent A, water-immiscible organic solvent B and/or dispersion C.
Dependencies are inferred from the claim text.