Pharmaceutical Compositions Containing Diacerein
AssigneeTWi Biotechnology, Inc.
InventorsDanchen Gao, Jen-Sen Wu, Wei-Shu Lu, Shouchiung Chen, Pei-Chun Kuo, Chih-Ming Chen
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Abstract
A once-daily controlled-release formulation of diacerein for treating inflammatory or autoimmune diseases or their complications, with reduced adverse side effects and methods of treating such diseases are disclosed.
Claims20
A once-daily controlled-release formulation of diacerein for treating inflammatory diseases, autoimmune diseases or their complications with reduced adverse side effects, comprising an active layer, a sustained-release film layer, and a delayed-release film layer, wherein said sustained-release film layer comprises an ethyl cellulose polymer, povidone, triethyl citrate and talc, and wherein said delayed-release film layer comprises an Eudragit® polymer, triethyl citrate and talc.
The controlled-release formulation according to claim 21, wherein said active layer comprises about 50.0% by weight of microcrystalline cellulose, about 25.0% by weight of diacerein, about 2.0% by weight of povidone and about 23.0% by weight of mannitol.
Dependencies are inferred from the claim text.