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AssigneeModerna Therapeutics, Inc.
InventorsAntonin de Fougerolles, Kristy M. Wood, Sayda M. Elbashir, Noubar B. Afeyan, Pedro Valencia, Jason P. Schrum
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The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
A method of producing a polypeptide of interest in a mammalian cell or tissue, the method comprising, contacting said mammalian cell or tissue with a formulation comprising a modified mRNA encoding the polypeptide of interest, wherein the formulation is selected from the group consisting of nanoparticles, poly(lactic-co-glycolic acid) (PLGA) microspheres, lipidoid, lipoplex, liposome, polymers, carbohydrates (including simple sugars), cationic lipids, fibrin gel, fibrin hydrogel, fibrin glue, fibrin sealant, fibrinogen, thrombin, rapidly eliminated lipid nanoparticles (reLNPs) and combinations thereof.
A method of producing a polypeptide of interest in a mammalian cell or tissue, the method comprising, contacting said mammalian cell or tissue with a buffer formulation comprising a modified mRNA encoding the polypeptide of interest.
A method of producing a pharmacologic effect in a primate comprising contacting said primate with a composition comprising a formulated modified mRNA encoding a polypeptide of interest.
Dependencies are inferred from the claim text.