Lipid formulated single stranded rna
AssigneesAlnylam Pharmaceuticals, Inc., Isis Pharmaceuticals, Inc.
InventorsMuthiah Manoharan, Sayda Elbashir, Kallanthottathil G. Rajeev, Thazha P. Prakash, Walter F. Lima, Eric E. Swayze
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions comprising a nucleic acid lipid particle and an oligomeric compound and uses thereof. In certain embodiments, such compositions are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.
Claims32
A composition comprising a nucleic acid lipid particle comprising a single stranded RNA, wherein the nucleic acid lipid particle comprises a lipid formulation comprising 45-65 mol % of a cationic lipid, 5 mol % to about 10 mol %, of a non-cationic lipid, 25-40 mol % of a sterol, and 0.5-5 mol % of a PEG or PEG-modified lipid.
Dependencies are inferred from the claim text.