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US 2013/0156807 A1Published application
Conjugates of synthetic tlr agonists and uses therefor
AssigneeThe Regents of the University of California
InventorsDennis A. Carson, Howard B. Cottam, Woldgang Wrasidlo, Christina C.N. Wu, Gregory A. Daniels
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Abstract
The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
Claims12
A method for inducing an immune response in a mammal comprising:
- administering to a mammal a compound of formula A in an amount effective to induce an immune response in the mammal, the compound of formula A having the structure:
- or a pharmaceutically acceptable salt thereof, wherein:
- X1 is —O—;
- R1 is hydrogen, (C1-C10)alkyl or (C1-C10)alkyl substituted with (C1-C6)alkoxy;
- X2 is C(O);
- and
- R3 is dioleoylphosphatidyl ethanolamine (DOPE).
4 more elements
Dependencies are inferred from the claim text.