Cholera Toxin Chimera and its Use as a Staph Vaccine
AssigneeBoise State University
InventorJuliette Tinker
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Abstract
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.
Claims20
A method of generating an immune response in a mammal comprising:
- administering to the mammal a composition comprising:
- a chimeric protein comprising at least one of:
- a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin;
- and
- an antigen comprising at least one of:
- an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.
A method of vaccinating a cow comprising:
- administering to the cow, a chimeric protein comprising:
- an adjuvant selected from the group consisting of:
- a portion of a cholera toxin, a portion of a heat-labile toxin, a portion of a shiga toxin, and any combination thereof;
- and
- an antigen selected from the group consisting of:
- an antigenic material from S. aureus, an antigenic material from an S. aureus-specific polypeptide, and any combination thereof.
Dependencies are inferred from the claim text.