Contiguous overlapping peptides for treatment of birch pollen allergy
AssigneeAnergis S.A.
InventorsChristophe Reymond, Francois Spertini
Life of this patent
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Abstract
Contiguous overlapping peptides (COPs) for the treatment of allergic patients by Specific Immunotherapy (SIT) are provided from the sequence of the major allergen of birch pollen Bet v 1. Such peptides while providing all potential T cell epitopes are devoid of the 3D structure of the original allergen, therefore reducing their ability to bind IgE.
Claims15
A composition comprising a plurality of contiguous overlapping peptide fragments comprising a first peptide having 90% sequence identity with the peptide consisting of the sequence from amino acid 2 to amino acids 42-52 of SEQ ID NO:
- 9 wherein the reactivity of said first peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained;
- a second polypeptide having 90% sequence identity with the peptide consisting of the sequence from amino acids 42-52 to amino acids 96-131 of SEQ ID NO:
- 9 wherein the reactivity of said second peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained and a third peptide having 90% sequence identity with the peptide consisting of the sequence from amino acids 96-131 to amino acid 160 of SEQ ID NO:
- 9 wherein the reactivity of said third peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained.
A peptide having 90% sequence identity with the peptide consisting of the sequence from amino acid 2 to amino acids 42-52 of SEQ ID NO:
- 9 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained.
A peptide having 90% sequence identity with the peptide consisting of the sequence from amino acids 42-52 to amino acids 96-131 of SEQ ID NO:
- 9 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained.
A peptide having 90% sequence identity with the peptide consisting of the sequence from amino acids 96-131 to amino acid 160 of SEQ ID NO:
- 9 wherein the reactivity of said peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained.
A method of specific immunotherapy against birch pollen allergies comprising administering to a patient in need thereof one or more allergens selected from the group consisting of a first peptide having 90% sequence identity with the peptide consisting of the sequence from amino acid 2 to amino acids 42-52 of SEQ ID NO:
- 9 wherein the reactivity of said first peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained;
- a second polypeptide having 90% sequence identity with the peptide consisting of the sequence from amino acids 42-52 to amino acids 96-131 of SEQ ID NO:
- 9 wherein the reactivity of said second peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained and a third peptide having 90% sequence identity with the peptide consisting of the sequence from amino acids 96-131 to amino acid 160 of SEQ ID NO:
- 9 wherein the reactivity of said third peptide to IgE antibodies of subjects who are allergic to birch pollen is eliminated while the reactivity with the T lymphocytes from subjects who are allergic to birch pollen is retained.
Dependencies are inferred from the claim text.