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AssigneesThe Trustees of the University of Pennsylvania, The Children's Hospital of Philadelphia
InventorsRobert J. Levy, Michael Chorny, Vladimir Muzykantov, Elizabeth Hood
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Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
A therapeutic particle comprising a magnetic or magnetizable material, a stabilizer, a fatty acid or salt thereof, and a protein.
A method for protecting a cell from oxidative damage, comprising contacting the cell with a particle comprising a magnetic or magnetizable material and at least one antioxidant enzyme, and generating a uniform magnetic field capable of magnetizing the magnetic or magnetizable material proximal to the cell for a period of time sufficient to permit the cell to internalize the particle.
A method for magnetically targeting a protein to an implanted device, comprising the steps of:
Dependencies are inferred from the claim text.