Novel diagnostic and therapeutic target in inflammatory and/or cardiovascular diseases
AssigneeUniversity of Zurich
InventorsChad Brokopp, Simon Hoerstrup
Life of this patent
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Abstract
Methods for diagnosing inflammatory and/or cardiovascular diseases by assaying for Fibroblast Activation Protein (FAP) expression in a body fluid is provided as well as therapeutic means based thereon.
Claims26
A method of determining the presence of an inflammatory and/or cardiovascular disease or condition in a patient comprising assaying
- (i) a sample of a body fluid taken from said patient for expression of Fibroblast Activation Protein (FAP), wherein expression or an increased expression of said FAP compared to a control sample is indicative for the disease or condition in said patient;
- and/or
- (ii) a sample of a thrombus or plaque taken from said patient for expression of FAP, wherein an increased expression of FAP as compared to its expression in a sample of a body fluid taken from said patient is indicative for the disease or condition.
A method of treating a disease selected from the group atherosclerosis, rheumatoid arthritis, stroke or an acute coronary syndrome such as myocardial infarction, heart attack, chronic liver disease, cerebral venous thrombosis, deep venous thrombosis or pulmonary embolism, said method comprising administering to a patient a composition comprising a compound capable of inhibiting the activity of FAP or its expression.
A method of preventing or treating a coagulation disorder, said method comprising administering to a patient a pharmaceutical composition comprising FAP.
A method of using FAP as a reagent for enhancing blood clotting in vitro.
A method of using ROTEM/NATEM for testing the therapeutic effect and/or efficiency of FAP blocking agents in a patient.
A method of diagnosing a disease selected from the group atherosclerosis, rheumatoid arthritis, stroke or an acute coronary syndrome such as myocardial infarction, heart attack, chronic liver disease, cerebral venous thrombosis, deep venous thrombosis or pulmonary embolism using a composition comprising a compound capable of detecting the presence or activity of FAP.
Dependencies are inferred from the claim text.