Anti-dr4 agonist antibodies
AssigneeThe Govt. of the United States of America H.H.N.I. H., Office of Technology Transfer
InventorsDimiter Dimitrov, Yang Feng
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Abstract
The present invention provides antibodies and antibody fragments that specifically recognize and agonize the death receptor 4 (DR4). Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors.
Claims23
An antibody that binds to and is an agonist of DR4, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region and the light chain variable region each comprise the following three complementary determining regions (CDRs):
- CDR1, CDR2 and CDR3;
- wherein:
- i) the CDR1 of the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:8;
- ii) the CDR2 of the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:9;
- iii) the CDR3 of the heavy chain variable region comprises an amino acid sequence selected from SEQ ID NO:10 or SEQ ID NO:13;
- iv) the CDR1 of the light chain variable region comprises the amino acid sequence of SEQ ID NO:5;
- v) the CDR2 of the light chain variable region comprises the amino acid sequence of SEQ ID NO:31;
- vi) the CDR3 of the light chain variable region comprises the amino acid sequence of SEQ ID NO:30.
Dependencies are inferred from the claim text.