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AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsNeil James Clarke, Kyung Oh Johanson, Zdenka Ludmila Jonak, Alexander H. Taylor, Christopher B. Hopson, Stephen H. Trulli, Zdenka Haskova, Judithann M. Lee, John R. White, Yu Xue
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The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.
1-12. (canceled)
An antigen binding protein comprising a heavy chain variable region having at least one CDR with greater than 75% sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NO:
17-23. (canceled)
An antigen binding protein comprising a heavy chain variable region sequence having the amino acid sequence shown in SEQ ID NO:
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An antigen binding protein which specifically binds to a peptide chain domain comprising amino acid residues 330 to 495 of SEQ ID NO:
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An antigen binding protein which specifically binds a HER3 receptor and comprises CDRH1 having the amino acid sequence shown in SEQ ID NO:
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87-91. (canceled)
An antigen binding protein comprising a heavy chain sequence having amino acid residues 20 to 466 of the amino acid sequence shown in SEQ ID NO:
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97-98. (canceled)
An isolated nucleic acid encoding amino acid residues 20 to 238 of the amino acid sequence shown in SEQ ID NO:
An isolated nucleic acid encoding amino acid residues 20 to 466 of the amino acid sequence shown in SEQ ID NO:
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A method for the production of an antigen binding protein comprising the steps of:
127-137. (canceled)
An isolated nucleic acid comprising the nucleic acid sequence shown in SEQ ID NO:
An isolated nucleic acid comprising the nucleic acid sequence shown in SEQ ID NO:
A method for the production of an antigen binding protein comprising the steps of:
Dependencies are inferred from the claim text.