Lung regeneration using cord blood-derived hematopoietic stem cells
AssigneeWomen & Infants Hospital of Rhode Island
InventorMonique E. Depaepe
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Abstract
Described herein are novel approaches for regenerating injured or defective lung epithelium for the treatment of respiratory disorders using, in part, cord blood-derived hematopoietic stem cells. The methods and uses described herein relate to the administration of or use of hematopoietic stem cells, specifically those isolated or enriched from umbilical cord blood, to a subject in need thereof having a respiratory disorder, such as BPD, or any disorder characterized by insufficient or defective or injured lung epithelium or lung vasculature.
Claims42
A method for treating or preventing a lung disorder in a subject in need thereof, comprising administering a therapeutically effective amount of a population of isolated or enriched umbilical cord blood derived hematopoietic stem cells to said subject.
A method for repairing or reconstituting or generating pulmonary epithelium in a subject in need thereof, comprising administering a population of isolated or enriched umbilical cord blood derived hematopoietic stem cells to said subject.
A method for repairing or reconstituting or generating pulmonary vasculature or pulmonary endothelium in a subject in need thereof, comprising administering a population of isolated or enriched umbilical cord blood derived hematopoietic stem cells to said subject.
A method for repairing or reconstituting pulmonary alveoli in a subject in need thereof, comprising administering a population of isolated or enriched umbilical cord blood derived hematopoietic stem cells to said subject.
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Dependencies are inferred from the claim text.