FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS

A stradomer unit comprising:

• (a) a leader sequence
• (b) an IgG1 Fc domain;
• and
• (c) a multimerization domain;
• wherein the leader sequence is directly linked to the IgG1 Fc domain and wherein the IgG1 Fc domain is directly linked to the multimerization domain or wherein the leader sequence is directly linked to the multimerization domain and the multimerization domain is directly linked to the IgG1 Fc domain.

The method of claim 19 further comprising

• (a) cloning a DNA encoding the stradomer selected from the group consisting of SEQ ID NO:4, SEQ ID NO:8, or SEQ ID NO:
• 18 into an expression vector;
• (b) transfecting the expression vector into a bacterial host;
• (c) isolating the plasmid DNA containing cloned DNA from the bacterial culture;
• (d) linearizing the plasmid DNA containing cloned DNA;
• (e) transfecting the linearized DNA into mammalian cells;
• (f) expanding the positively transfected cells to obtain a pool of stably transfected cells;
• (g) harvesting the stradomer protein from the media;
• and
• (h) purifying the stradomer protein, wherein the stradomer protein contains no extraneous sequences.