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US 2013/0156744 A1Published application
Methods of recellularizing a tissue or organ for improved transplantability
AssigneeRegents of the University of Minnesota
InventorsDoris Taylor, Stefan M. Kren
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Abstract
Described herein are methods of recellularizing an organ or tissue matrix.
Claims24
An ex vivo method of recellularizing a tissue or organ matrix, comprising the steps of:
- a) providing a tissue or organ matrix perfused with a physiological buffer under pressure;
- and
- b) reendothelializing the tissue or organ matrix by perfusing the tissue or organ matrix with a physiological composition comprising a substantially pure population of endothelial cells or endothelial progenitor cells.
A method of reducing thrombogenesis and immunogenicity in a recellularized tissue or organ following transplantation into a recipient, comprising:
- a) providing a tissue or organ matrix perfused with a physiological buffer under pressure;
- b) reendothelializing the tissue or organ matrix by perfusing the tissue or organ matrix with a physiological composition comprising a substantially pure population of endothelial cells or endothelial progenitor cells;
- and
- c) transplanting the reendothelialized tissue or organ matrix into the recipient.
1 more element
Dependencies are inferred from the claim text.