Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas

A compound having the formula:

• or a pharmaceutically acceptable salt thereof, wherein each dotted line represents an optional and additional bond, such that only one optional and additional bond can be attached to each of Y1 and Y2, and wherein:
• A is -alkylene-N(R7)(R11) or heterocycloalkyl, wherein said heterocycloalkyl group can be optionally and independently substituted on one or more ring nitrogen atoms with R4, and on one or more ring carbon atoms with R12, and wherein said heterocycloalkyl group can be optionally fused to a cycloalkyl group or an aryl group;
• B is monocyclic heteroarylene or bicyclic heteroarylene, wherein said monocyclic heteroarylene group or said bicyclic heteroarylene group can be optionally and independently substituted on one or more ring nitrogen atoms with R6, and on one or more ring carbon atoms with R12;
• C is a bond, monocyclic heteroarylene or bicyclic heteroarylene, wherein said monocyclic heteroarylene group or said bicyclic heteroarylene group can be can be optionally and independently substituted on one or more ring nitrogen atoms with R6 and on one or more ring carbon atoms with R12;
• D is -alkylene-N(R7)(R11) or heterocycloalkyl, wherein said heterocycloalkyl group can be can be optionally and independently substituted on one or more ring nitrogen atoms with R4, and on one or more ring carbon atoms with R12, and wherein a heterocycloalkyl can be optionally fused to a cycloalkyl group or an aryl group;
• M1 is a bond, —[C(R7)2]q—, —[C(R7)2]m—C(R2)═C(R2)—[C(R7)2]m—, —C(R7)═N—, —N═C(R7)—, —[C(R7)2]m—O—[C(R7)2]m, —O—[C(R7)2]q—O—, —[C(R7)2]m—N(R6)—[C(R7)2]m—, —S—, —[C(R7)2]-S(O)m—[C(R7)2]m—, —[C(R7)2]m—OC(O)N(R6)—[C(R7)2]m, —[C(R7)2]m—N(R6)C(O)N(R6)—[C(R7)2]m—, —[C(R7)2]m—S(O)2N(R6)—[C(R7)2]m— or —[C(R7)2]m—N(R6)S(O)2N(R6)—[C(R7)2]m—;
• M2 is a bond, —[C(R7)2]q—, —[C(R7)2]m—C(R2)═C(R2)—[C(R7)2]m—, —C(R7)═N—, —N═C(R7)—, —[C(R7)2]m—O—[C(R7)2]m, —O—[C(R7)2]q—O—, —[C(R7)2]m—N(R6)—[C(R7)2]m—, —S—, —[C(R7)2]m—S(O)m—[C(R7)2]m—, —[C(R7)2]m—OC(O)N(R6)—[C(R7)2]m—, —[C(R7)2]m—N(R6)C(O)N(R6)—[C(R7)2]m—, —[C(R7)2]m—S(O)2N(R6)—[C(R7)2]m— or —[C(R7)2]m—N(R6)S(O)2N(R6)—[C(R7)2]m—, such that at least one of M1 and M2 is other than a bond, and such that the central ring of formula (I) that contains M1 and M2 has from 5 to 10 total ring atoms, and wherein two vicinal R7 groups of M1 or M2 together with the carbon atoms to which they are attached, can optionally join to form a 3- to 7-membered cycloalkyl group, a 3- to 7-membered heterocycloalkyl group, or a 5- to 6-membered heteroaryl group;
• X1 is a bond, —C(R2)═C(R2)—, —N═C(R5)—, —C(R5)═NC—, —C(R5)═N—, —O—, —N(R6)—, —S— or —S(O)2— when the optional and additional bond to X1 is not present, and X1 is —C(R5)—, is —C(R5)(C(R5)=(C(R5)—, —N—, —N—C(R5)═C(R5)—, —C(R5)N═C(R5)—, —C(R5)C(R5)═N—, —C(R5)O—, —C(R5)N(R6)—, —N—N(R6)—, —C(R5)S— or —C(R5)S(O)2— when the optional and additional bond to X1 is present, such that X1 and Z1 cannot each be a bond, and such that when X1 is —C(R5)—, —N(R6)—, —N—, or —O—, then Z1 is other than a bond;
• X2 is a bond, —C(R2)═C(R2)—, —N═C(R5)—, —C(R5)N═C—, —C(R5)═N—, —O—, —N(R6)—, —S— or —S(O)2— when the optional and additional bond to X2 is not present, and X2 is —C(R5)—, is —(C(R5)=(C(R5)C(R5—, —C(R5)═C(R5)N—, —C(R5)═NC(R5)—, —N═C(R5)C(R5)—, —OC(R5)—, —N(R6)C(R5)—, —N(R6)—N—, —S—C(R5)— or —S(O)2C(R5)— when the optional and additional bond to X2 is present, such that X2 and Z2 cannot each be a bond, and such that when X2 is —C(R5)— —N(R6)—, —N—, or —O—, then Z2 is other than a bond;
• Y1 is —C—, when an optional and additional bond to Y1 is present, and Y1 is —CH— when an optional and additional bond to Y1 is absent;
• Y2 is —C—, when an optional and additional bond to Y2 is present, and Y2 is —CH— when an optional and additional bond to Y2 is absent;
• Z1 is a bond, —C(R5)═C(R5)—, —N═C(R5)—, —C(R5)═NC—, —C(R5)═N—, —O—, —N(R6)—, —S— or —S(O)2— when the optional and additional bond to Z1 is not present, and Z1 is —C(R5)—, —C(R5)(CH(R5))m—, —N—, —NCH(R5)CH(R5)—, —C(R5)NHCH(R5)—, —C(R5)CH(R5)NH—, —C(R5)O—, —C(R5)N(R6)—, —N—N(R6)—, —C(R5)S— or —C(R5)S(O)2— when the optional and additional bond to Z1 is present, such that the ring in formula (I) containing X1, Y1 and Z1 has 5 or 6 total ring atoms;
• Z2 is a bond, —C(R5)═C(R5)—, —N═C(R5)—, —C(R5)N═C—, —C(R5)═N—, —O—, —N(R6)—, —S— or —S(O)2— when the optional and additional bond to Z2 is not present, and Z2 is —C(R5)—, —(CH(R5)mC(R5)—, —CH(R5)CH(R5)N—, —CH(R5)NHC(R5)—, —NHCH(R5)C(R5)—, —OC(R5)—, —N(R6)C(R5)—, —N(R6)—N—, —S—C(R5)— or —S(O)2C(R5)— when the optional and additional bond to Z2 is present, such that the ring in formula (I) containing X2, Y2 and Z2 has 5 or 6 total ring atoms;
• each occurrence of R1 is independently C1-C6 alkyl, C1-C6 haloalkyl, aryl, 3 to 7 membered cycloalkyl, 4 to 7 membered heterocycloalkyl or heteroaryl, wherein said aryl group, said cycloalkyl group, said heterocycloalkyl group or said heteroaryl group can be optionally and independently substituted with up to three R2 groups;
• each occurrence of R2 is independently C1-C6 alkyl, aryl, 3 to 7 membered cycloalkyl, 4 to 7 membered heterocycloalkyl, heteroaryl, halo, C1-C6 haloalkyl, —CN, —OR3, —N(R3)2, —C(O)R10, —C(O)OR3, —C(O)N(R3)2, —NHC(O)R10, —NHC(O)NHR3, —NHC(O)OR3, —OC(O)R10, —SR3 or —S(O)2R1;
• each occurrence of R3 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, aryl, 3 to 7 membered cycloalkyl, 4 to 7 membered heterocycloalkyl or heteroaryl, wherein said aryl group, said cycloalkyl group, said heterocycloalkyl group or said heteroaryl group can be optionally and independently substituted with up to three groups independently selected from hydroxy, halo, alkyl, aminoalkyl, and haloalkyl.
• each occurrence of R4 is independently H, —C(O)—[C(R7)2]qN(R6)2, —C(O)—[C(R7)2]qN(R6)C(O)—R1, —C(O)—[C(R7)2]qN(R6)C(O)O—R1, —C(O)—[C(R7)2]qC(O)O—R1, —C(O)[C(R7)2]qN(R6)SO2—R1 or -alkylene-N(R6)—[C(R7)2]q—N(R6)—C(O)O—R1;
• each occurrence of R5 is independently H, C1-C6 alkyl, 3 to 7-membered cycloalkyl, aryl or heteroaryl;
• each occurrence of R6 is independently H, C1-C6 alkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl, or heteroaryl, wherein said aryl group, said cycloalkyl group, said heterocycloalkyl group or said heteroaryl group can be optionally and independently substituted with up to two R8 groups, and wherein two R6 groups that are attached to a common nitrogen atom, together with the nitrogen atom to which they are attached, can optionally join to form a 4 to 7-membered heterocycloalkyl group;
• each occurrence of R7 is independently H, C1-C6 alkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl, heteroaryl, wherein said aryl group, said cycloalkyl group, said heterocycloalkyl group or said heteroaryl group can be optionally and independently substituted with up to 3 substituents, which can be the same or different, and are selected from C1-C6 alkyl, halo, —C1-C6haloalkyl, C1-C6 hydroxyalkyl, —OH, —C(O)NH—(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)2, —O—(C1-C6 alkyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2 and —NHC(O)—(C1-C6 alkyl), and wherein two geminal R7 groups, together with the common carbon atom to which they are attached, can optionally join to form —C(O)—, —C(S)—, —C(═NR9)—, —C(═NOR9)—, a 3 to 7-membered cycloalkyl group or a 4 to 7-membered heterocycloalkyl group, such that no two adjacent —C(R7)2— groups can join to form a —C(O)—C(O)—, —C(S)—C(S)—, —C(O)—C(S)— or —C(S)—C(O)— group;
• each occurrence of R8 is independently H or C1-C6 alkyl;
• each occurrence of R9 is independently H, C1-C6 alkyl, 3 to 7-membered cycloalkyl or 4 to 7-membered heterocycloalkyl;
• each occurrence of R10 is independently C1-C6 alkyl, C1-C6 haloalkyl, aryl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl or heteroaryl;
• each occurrence of R11 is independently —C(O)—[C(R7)2]qN(R6)2, —C(O)—[C(R7)2]qN(R6)C(O)—R1, —C(O)—[C(R7)2]qN(R6)C(O)O—R1, —C(O)—[C(R7)2]qC(O)O—R1, —C(O)[C(R7)2]qN(R6)SO2—R1 or -alkylene-N(R6)—[C(R7)2]q—N(R6)—C(O)O—R1;
• each occurrence of R12 is H, C1-C6 alkyl, 3 to 7-membered cycloalkyl, 4 to 7-membered heterocycloalkyl, aryl, heteroaryl, halo, C1-C6 haloalkyl, —CN, —OR3, —N(R3)2, —C(O)R10, —C(O)OR3, —C(O)N(R3)2, —NHC(O)R10, —NHC(O)NHR3, —NHC(O)OR3, —OC(O)R10, —SR3 or —S(O)2R1;
• and wherein two R12 groups together with the carbon atoms to which they are attached, can optionally join to form a 5 to 7-membered cycloalkyl or 4 to 7-membered heterocycloalkyl group;
• each occurrence of m is independently an integer ranging from 0 to 2;
• and
• each occurrence of q is independently an integer ranging from 1 to 4.