Mammalian Receptor Proteins; Related Reagents and Methods
AssigneeMerck Sharp & Dohme Corp.
InventorsMadaline Chirica, Robert A. Kastelein, Kevin Moore, Christi L. Parham
Life of this patent
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Abstract
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
Claims17
A method of treating a human subject experiencing a physiological disorder comprising administering an effective amount of an agonist or antagonist of DCRS5 (SEQ ID NOs:1 or 2) or of p19 (SEQ ID NOs:5 or 6), wherein the disorder comprises:
- a) rheumatoid arthritis;
- b) asthma or allergy;
- c) chronic obstructive pulmonary disorder (COPD);
- d) an interstitial lung disorder;
- e) an inflammatory bowel disorder (IBD);
- or
- f) an inflammatory skin disorder.
A method of diagnosing a physiological disorder comprising contacting a binding composition that specifically binds to DCRS5 (SEQ ID NOs:1 or 2), or to p19 (SEQ ID NOs:5 or 6), to a sample derived from a test subject experiencing:
- a) rheumatoid arthritis;
- b) asthma or allergy;
- c) chronic obstructive pulmonary disorder (COPD);
- d) an interstitial lung disorder;
- e) inflammatory bowel disorder (IBD);
- or
- f) an inflammatory skin disorder.
Dependencies are inferred from the claim text.