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AssigneeUniversidade De Santiago De Compostela
InventorsCarmen Alvarez Lorenzo, Ana Rey Rico, Teresa Silva Rivera, José Couceiro Follente, Angel Concheiro Nine
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The invention describes for first time the activity of poloxamines as inducers in the differentiation of mesenchymal or progenitor cells. In particular, the invention demonstrates that poloxamines have an osteogenic ability. The invention relates to the use of one or more poloxamines or a pharmaceutical composition comprising same for the preparation of a drug for treting patients with bone defects in general. The invention also relates to a method for inducing the differentiation of mesenchymal or progenitor cells into osteoblasts by bringing said cells into contact with a sterilised aqueous dispersion or solution of one or more poloxamines.
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A method for inducing differentiation of mesenchymal or stem cells comprising administration to a patient in that need thereof a therapeutically effective amount of one or more poloxamines.
A method for treatment of bone defects, the method comprising administering a therapeutically effective amount of one or more poloxamines to a patient in the need of said treatment.
A pharmaceutically acceptable composition consisting of one or more poloxamines and one or more excipients.
A method in vitro for inducing differentiation of mesenchymal or stem cells, except human embryonic stem cells, into osteoblasts, the method comprising contacting a) a sterilized solution or aqueous dispersion of one or more poloxamines, with b) mesenchymal or stem cells, except human embryonic stem cells, which are in a culture medium.
A method for inducing differentiation of mesenchymal or stem cells, comprising contacting mesenchymal or stem cells with one or more poloxamines.
A method for treating at least one of the following conditions (i) to (iv):
Dependencies are inferred from the claim text.