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US 2013/0156706 A1Published application
Targeted gas-filled microvesicles
AssigneeBracco Suisse SA
InventorsThierry Bettinger, Philippe Bussat, Samir Cherkaoui, Irene Guilbert-Brigger, Bernard Lamy
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Abstract
Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.
Claims37
An aqueous suspension comprising a gas-filled microvesicle, said microvesicle comprising a targeting construct comprising:
- a) an amphiphilic compound;
- and
- b) a polypeptide consisting of at most 200 amino acid residues and comprising at least amino acids 5-16 as set forth in SEQ ID NO:1;
- said polypeptide being in dimeric form and being covalently associated with said amphiphilic compound.
1 more element
(canceled)
13-14. (canceled)
18-19. (canceled)
(canceled)
31-32. (canceled)
Dependencies are inferred from the claim text.