Methods for the treatment and the diagnosis of cancer
AssigneeInstitut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsGérard Friedlander, Laurent Beck, Christine Salaün, Christine Leroy
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Abstract
The present invention relates to methods for the diagnostic and the staging of cancer such as liver cancer. The present invention also relates to methods for the treatment of cancer including liver cancer such as hepatocellular carcinoma (HCC).
Claims24
A method for detecting or diagnosing a cancer and/or metastases in a patient comprising the step of determining an expression level of the phosphate transporter PiT1 gene in a biological sample obtained from said patient.
A method for staging a cancer in a patient having cancer comprising the step of determining an expression level of the PiT1 gene in a biological sample obtained from said patient.
A method for screening an asymptomatic patient at risk for cancer, said method comprising the step of determining an expression level of the PiT1 gene in a biological sample obtained from said patient.
A method of detecting and localizing cancer cells and/or metastases stemming from cancer cells in the body of a patient, comprising the steps of
- administering to said patient a labeled agent which binds to PiT1 in a quantity sufficient for imaging said patient,
- subjecting said body to imaging to produce images, and
- using said images to detect and localize said cancer cells and/or said metastases.
A kit for detecting or diagnosing a cancer and/or metastases in a patient, wherein said kit comprises means for determining the expression level of a PiT1 gene in a biological sample obtained from said patient.
A kit for detecting and localizing cancer cells and/or metastases stemming from cancer cells in the body of a patient, wherein said kit comprises a labelled agent which binds to PiT1.
A method for preventing or treating a cancer in a patient, comprising the step of administrating an effective amount of an inhibitor of the activation of PiT1 to a subject in need thereof.
A method for preventing or treating a cancer in a patient, comprising the step of administering to said patient an effective amount of PiT1-specific binding molecule conjugated to a chemotherapeutic agent.
A pharmaceutical composition comprising an inhibitor of the activation of PiT1 or a PiT1-specific binding molecule conjugated to a chemotherapeutic agent.
A method for screening a drug for the prevention or the treatment of cancer comprising the steps consisting of:
- a) providing a plurality of cells expressing PiT1 on their surface;
- b) incubating said cells with a candidate compound;
- c) determining whether said candidate compound binds to and inhibits PiT1;
- and
- d) selecting the candidate compound that binds to and inhibits PiT1, and optionally
- e) administering the candidate compound selected at step d) to an animal model of cancer to validate the therapeutic and/or protective effects of said candidate compound.
Dependencies are inferred from the claim text.