Back to results
US 2013/0156699 A1Published application
Radiolabeled compounds and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJoseph John MANN, J.S. Dileep KUMAR
Life of this patent
Estimating the term…
Abstract
The present invention relates to Radiolabeled Compounds labeled with fluorine, bromine, iodine, carbon, or tritium isotopes and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.
Claims24
A compound having the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- r and s are each independently an integer ranging from 0 to 3;
- R1 is —C1-C6 alkyl,
- R2 is —H, and
- R3 is -aryl, -heteroaryl or -napththyl, each of which is substituted with 75Br, 76Br, 120I, 123I, 124I, 125I, 131I, or —OC3HH2.
3 more elements
A compound having the formula:
- or a pharmaceutically acceptable salts thereof,
- wherein:
- R1 is —C1-C6 alkyl,
- W is a bond or a carbonyl;
- and
- R3 is -aryl or -heteroaryl, each of which are optionally substituted with 18F, or —O—C1-C4alkyl, wherein —O—C1-C4alkyl is further substituted with 18F;
- and wherein said aryl or heteroaryl are optionally substituted with —CN.
4 more elements
Dependencies are inferred from the claim text.