Method for computing pharmacokinetic parameters in mri
AssigneeRajiv Gandhi Cancer Institute & Research Centre
InventorsAmarnath Jena, Shashi Bhushan Mehta, Sangeeta Taneja, Urmi Sarkar
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AssigneeRajiv Gandhi Cancer Institute & Research Centre
InventorsAmarnath Jena, Shashi Bhushan Mehta, Sangeeta Taneja, Urmi Sarkar
Estimating the term…
The present invention relates to a method of dynamic contrast magnetic resonance imaging aimed to improve characterization of tissue image by improving accuracy of computed pharmacokinetic parameters such as Ktrans (transfer constant across capillary membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing accurate T1 value of a tissue after the contrast is injected based on an intrinsic T10 value the tissue, wherein the intrinsic T10 value is adjusted and/or normalized to improve accuracy of the T1 value computed, which in turn is used for computation of pharmacokinetic parameters at least one of Ktrans.
A method of computing pharmacokinetic parameters comprising:
A computer system comprising:
A magnetic resonance imaging (MRI) system comprising a controller for causing computation of pharmacokinetic parameters by the steps of
Dependencies are inferred from the claim text.