Aphicidal Toxins and Methods
OwnerBryony Claire Bonning, Sijun Liu +1inventors
InventorsBryony Claire Bonning, Sijun Liu, Huarong Li
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OwnerBryony Claire Bonning, Sijun Liu +1inventors
InventorsBryony Claire Bonning, Sijun Liu, Huarong Li
Estimating the term…
Provided are chimeric aphicidal and insecticidal toxin proteins comprising peptide, peptide multimer or fusion protein containing such peptide which binds to the gut of sap-sucking insects, e.g., aphids, thrips, leafhoppers, or other target interest. When bound, this peptide mediates the binding of the chimeric aphicidal or other insecticidal protein to the target insect gut. Also described are coding sequences, vectors, and transgenic plants genetically modified to contain and express such aphicidal or insecticidal proteins. Thus, the use of such transgenic plants reduces economic loss due to feeding by the target insect and also reduces loss due to plant diseases spread by the target insect.
A chimeric insecticidal protein comprising an insect toxic portion and at least one target insect gut binding peptide or target insect gut binding peptide multimer portion, wherein said gut binding peptide is characterized by an amino acid sequence conforming to the consensus sequence of SEQ ID NO:21 (Xaa1-Xaa2-Cys-Ser-Xaa6-Xaa6-Tyr-Pro-Xaa3-Ser-Xaa4-Cys-Xaa5-Xaa6, wherein Xaa1 and Xaa6, independently of one another, can be any amino acid or no amino acid;
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