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AssigneeRutgers, The State University of New Jersey
InventorsTugrul Ozel, Thanongsak Thepshonti, Nicola Milesi
Estimating the term…
A micro-needle array is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface, a bottom surface, a side surface, and a cavity defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface. A plurality of micro-needles on a patch is also disclosed for transdermal drug delivery applications.
A micro-milled patch comprising a plurality of micro-needles, said micro-needles comprising a structure comprising a base at a proximal end and a vertex or tip, defining a vertex angle, at a distal end, said needle not extending into the dermis when applied to the skin, wherein said micro-needle is optionally biodegradable.
A single flute straight cutting edge tungsten carbide engraving tool for fabrication of micro-needles having the geometrical parameters of Table 2.
Dependencies are inferred from the claim text.