Nucleic acid based cardiovascular therapeutics
OwnerGabor Rubanyiinventor
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Abstract
The present invention relates to methods and compositions for delivering a nucleic acid to be expressed in the myocardium of a patient. More specifically, the present invention relates to techniques and polynucleotide constructs for treating heart disease by in vivo delivery of angiogenic transgenes.
Claims20
A method of delivering a vector comprising a nucleic acid to the myocardium of a patient, comprising the steps of:
- (a) inflating a balloon catheter within a coronary artery supplying blood to the myocardium to cause a first occlusion of myocardial blood flow, (b) allowing a first reperfusion of the myocardium by deflating the balloon catheter to release the first occlusion, (c) reinflating the balloon catheter to cause a second occlusion of myocardial blood flow, and (d) infusing a solution comprising the vector into the coronary artery downstream of the site of the second occlusion, and (e) allowing a second reperfusion of the myocardium by deflating the balloon catheter to release the second occlusion.
A combination comprising a medicament for the treatment of heart disease, wherein the medicament is for infusion into the myocardium through introduction into a coronary artery following induced occlusion, and a device for the occlusion of a coronary artery.
Dependencies are inferred from the claim text.