Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof
AssigneeYuhan Corporation
InventorsHyun Ju, Sang-Sun Joung, Hyun-Jik Yi, Ja-Heouk Khoo, Jong-Chul Lim, Jae-Gyu Kim
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AssigneeYuhan Corporation
InventorsHyun Ju, Sang-Sun Joung, Hyun-Jik Yi, Ja-Heouk Khoo, Jong-Chul Lim, Jae-Gyu Kim
Estimating the term…
The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
A process for preparing a compound of Formula 1, comprising converting a compound of Formula 4 to a compound of Formula 1:
Dependencies are inferred from the claim text.