Sirt4 activities
AssigneeMassachusetts Institute of Technology
InventorsLeonard P. Guarente, Marcia C. Haigis
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Abstract
Methods of modulating insulin secretion and treating metabolic disorders by modulating the expression or activity of Sirt4 are provided.
Claims14
A method of modulating insulin secretion in response to glucose, comprising modulating the expression or activity of Sirt4 in an insulin-secreting cell.
A method of treating or preventing a metabolic disorder, comprising administering to a subject an agent that modulates the expression or activity of Sirt4 in an amount effective to treat or prevent the metabolic disorder.
A method of treating or preventing a symptom of a neurodegenerative disorder, comprising administering to a subject a compound that increases the expression or activity of Sirt4 in an amount effective to treat or prevent the neurodegenerative disorder.
Dependencies are inferred from the claim text.