Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors

The compound of Formula Ill:

• wherein
• X1 represent OH or O—C1-6-alkyl;
• A1 is a bond or CH2;
• R1 is methyl or ethyl;
• R5 and R4 are H;
• R3 is tetrazole;
• X2 is halo;
• for each occurrence, R2 is independently C1-6-alkoxy, hydroxy, halo, C1-6-alkyl, cyano or trifluoromethyl;
• and
• p is 0 or an integer from 1 to 4;
• R6 for each occurrence is independently halo, hydroxy, C1-7alkoxy, halo, C1-7alkyl or halo-C1-7akyl;
• and
• s is 0 or an integer from 1 to 4;
• or a pharmaceutically acceptable salt thereof.